Pharmaniaga Morphine Sulphate Dosage/Direction for Use

Morphine sulphate should be given in the smallest effective dose and as infrequent as possible in order to minimise the development of tolerance and physical dependence. In patients with exceptionally severe, chronic pain or those who have become tolerant to the analgesic effect of opiate agonist, it may be necessary to exceed the usual dose.
Usual Adult dose: Analgesic: IM or SC: 5 - 20 mg (usually 10 mg initially) every 4 hours as needed.
IV: 4 - 10 mg diluted in 4 - 5 mL of sterile WFI administered slowly.
Epidural (in the lumbar region), 5 mg with incremental doses of 1 to 2 mg per hour if needed, up to a maximum of 10 mg per 24 hours.
Intrathecal, 0.2 mg - 1 mg as a single dose.
Usual Paediatric dose: Analgesic: SC: 0.1 to 0.2 mg/kg body weight every 4 hours as needed, not to exceed 15 mg per dose.
IV: 0.05 to 0.1 mg/kg body weight, administered very slowly.
Preoperative: IM : 0.05 mg to 0.1 mg/kg body weight, not to exceed 10 mg per dose.
ROUTE OF ADMINISTRATION: Parenteral [By IM, SC, Epidural, Intrathecal or slow IV injection].